【大师讲坛】第229期：Production of supply-limited natural product therapeutics using engineered yeast

2024-09-25 09:30:00-11:00:00
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The report will start with Professor Keasling's growth experience, focusing on how his lab utilizes microbial cell factories, metabolic engineering, and synthetic biology to produce complex natural products and intricate molecules that are beyond the reach of chemical synthesis.Plants produce some of the most potent human therapeutics and have been used for millennia to treat illnesses. Two examples are vinblastine, the chemotherapeutic, and QS-21, an adjuvant used in several vaccines. Both molecules are large, highly decorated terpenes. Vinblastine is extracted from Catharanthus roseus and requires 1 ton of dried leaves to obtain 1 g. In a similar vein, QS-21 is extracted from the tree bark of Quillaja saponaria, and its isolation is complicated as the plant extract contains a multitude of different structurally related Quillaja saponins, rendering the purification process highly laborious and low yielding. To alleviate supply issues, we have engineered Saccharomyces cerevisiae to produce these molecules.

嘉宾介绍

Jay D Keasling

美国国家工程院院士
演讲主题：Production of supply-limited natural product therapeutics using engineered
Jay Keasling is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling’s research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He was elected as a member of the National Academy of Engineering, a fellow of the American Academy of Arts and Sciences, a fellow of the National Academy of Inventors, a fellow of the American Society for Microbiology, and a fellow of the American Institute for Medical and Biological Engineering.
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