The lecture starts with presentations of results from the present research at the iHuman Institute of ShanghaiTech University, which is focused on allosteric mechanisms of transmembrane signaling by G protein-coupled receptors (GPCRs). This will be followed by some stories about my early days in scientific research and a short description of the project that led to the award of a Nobel Prize in Chemistry.
嘉宾介绍
Kurt Wüthrich
诺贝尔化学奖获得者、美国国家科学院外籍院士演讲主题：My Scientific Life with Magnetic Resonance in Biology and Medicine
Kurt Wüthrich was born in Aarberg, Switzerland in 1938 and obtained his Ph.D. in Inorganic Chemistry from the University of Basel, Switzerland in 1964. In 1977, he pioneered the application of two-dimensional nuclear magnetic resonance (2D NMR) to biopolymers, studying amino acids and bovine pancreatic trypsin inhibitor. Based on this work, he developed a method for the complete identification of individual peaks in 1H-NMR spectra of proteins using 2D NMR. Since 1980, he has been the Professor of Biophysics at the ETH Zurich, Zurich, Switzerland, and also serves as the Green Visiting Professor of Structural Biology at Scripps Research, La Jolla, CA, USA. He is additionally a Foreign Associate of the US National Academy of Sciences, a Foreign Associate of the French Academy of Sciences, a Foreign Member of the Latvian Academy of Sciences, and a Foreign Member of the Royal Society, UK. Contributions include the method for macromolecular structure determination with NMR in solution and the use of the principles of transverse relaxation-optimized spectroscopy (TROSY) for NMR experiments with large supramolecular assemblies. Applications over the years were focused on differentiation in higher organisms, immune suppression and neuropathology. He was awarded the 2002 Nobel Prize in Chemistry "for the development of methods for determining the three-dimensional structure of biological macromolecules in solution using nuclear magnetic resonance technique."