单分子光谱学在其应用的每一个领域都产生了巨大的影响，范围从催化、等离激元学、聚合物物理、生物物理到细胞生物学和DNA测序。此外，单分子技术使研究人员能够将荧光显微镜的分辨率推至衍射极限以下。在本次报告中，我将概述近年来（基于单分子的）显微镜模态的发展，这些发展与专用标记物和连接化学的合成密切相关。我将通过展示我实验室中当前的主要研究方向，来说明这些显微镜技术的发展如何推动了生物/材料科学的研究。
Single molecule spectroscopy has tremendously impacted every field in which the technique was applied, ranging from catalysis over plasmonics, polymer physics, biophysics to cell biology and DNA sequencing. Furthermore, single molecule techniques have allowed researchers to push the resolution of fluorescence microscopy past the diffraction limit. In this presentation, I will give an overview of recent (single molecule based) microscopy modality developments that go hand in hand with the synthesis of dedicated labels and linker chemistry. I will show how these microscopy developments have been driving research in bio/material science, by exemplifying major current research lines in my laboratory.
嘉宾介绍
Johan Hofkens
欧洲科学院院士Johan Hofkens, a professor in the Department of Chemistry at KU Leuven (Belgium) and a researcher at the Max Planck Institute for Polymer Research (Germany), is a member of both the Academia Europaea and the European Academy of Sciences, as well as a member of the Royal Flemish Academy of Belgium for Science and the Arts. Prof. Hofkens has long been dedicated to research in single-molecule spectroscopy, biophysics, catalytic energy conversion, and the development of novel perovskite materials. He is an internationally renowned molecular spectroscopist and has received awards such as the "Otto Wolfbeis Fluorescence Prize" and the "Proteomass Scientific Society Award." Prof. Hofkens has supervised over 100 PhD students and postdoctoral researchers at KU Leuven and has served as a visiting professor at several universities, including the University of Groningen, Lille 1 University, the University of Copenhagen, and the University of Parma. To date, he has published more than 1,000 academic papers in prestigious international journals such as Science, Nature, and Cell, with over 43,000 citations and an h-index of 112.